Cytokine Patterns in Iranian Patients with Asthma: A Narrative Review of Qualified Studies

Articles in Press

Document Type : Original Article

Authors

1 Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

2 Department of Allergy and Clinical Immunology, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran

10.22034/igj.2021.251374.1051

Abstract

Context: Asthma is one of the most common respiratory diseases caused by chronic airway inflammation. A complex network of cytokines could affect asthma development. In this study, we aimed to review studies investigating cytokine profile in Iranian asthmatic patients to introduce an appropriate cytokine biomarker related to asthma severity.
Evidence acquisition: We reviewed experimental studies investigating the cytokine levels and/or expression in the Iranian adult population with asthma until March 2, 2020, by using PubMed, Scopus, Science Direct, Google Scholar, and Embase databases. The terms used to search were including: “cytokine” or “interleukin”, “level” or “expression”, “asthma”, “biomarker”, and “Iran” for international databases.
Results: A total of 11 articles assessing the cytokine levels in adult asthmatic population were extracted from international databases and included in the current review. We investigated 10 cytokines in asthmatic and non-asthmatic subjects in Iran. Four cytokines (IL-4, IL-13, IL-17, and IL-33) were statistically higher and associated with asthma severity while IL-10 was lower in asthma patients in comparison to healthy subjects. There are controversies about IL-22, IL-25, and TGF-β levels between Iranian publications. There were no significant differences between healthy subjects and asthmatic ones regarding IL-6 and IL-8 levels.
Conclusion: Increased IL-4, IL-13, IL-17, and IL-33 levels are associated with asthma severity. These cytokines can be a candidate biomarker for predicting asthma severity among the Iranian population.

Keywords

Immunology and Genetics Journal

Articles in Press, Accepted Manuscript
Available Online from 05 January 2021

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